Is animal agriculture increasing the risk of disease and pandemics?

By Caitlin Owen

Zoonoses are diseases transmitted between humans and vertebrates. These are relatively rare but potentially devastating events. About 60% of human infections are estimated to have originated from animals1, and this phenomenon is becoming more frequent2. 75% of new and emerging diseases are zoonotic3, and most pandemics are caused by zoonoses4.

Zoonotic diseases can emerge when a genetic change happens which allows pathogens to ‘jump’ from animals to humans. Some pathogens may even combine genetic material with each other, allowing them to transfer advantageous mutations and the ability to infect animals and humans. This is thought to have occurred for the 2006 ‘swine flu’ pandemic, caused by an H1N1 virus which features a mix of genetic sequences from various human, avian and swine influenza viruses5.

Increasing demand for animal agriculture may be increasing the risk of new zoonoses forming.

Tens of billions of animals are killed every year for human consumption6. How does this industry meet our excessive demand for animal products and profits? How do its practices impact on global disease spread?

Disease becomes more likely when large numbers of genetically similar animals of the same species are kept extremely close together4.
Even “free-range” hens may  be kept with ~13 birds per square metre in the UK7. In the US, they simply have to be outside8. Livestock are prevented from moving around to prevent wasting of energy that could be spent on growth. Animals have also been selectively bred with genes that make them better products, causing much of livestock to be genetically similar in favour of bigger chicken breasts, or increased milk production4. Low genetic diversity in any population increases its overall susceptibility to certain diseases9, and when animals are kept close together10, especially in poor welfare conditions where they cannot escape the waste of other animals11, or are frequently injured, an ideal breeding ground is presented for pathogens to spread and mutate quickly.

One way that the industry has compensated for this is through mixing antibiotics into animal feed and water supplies, leading to overuse4;12.
Antibiotics are antimicrobial agents produced naturally by bacteria to reduce the competition presented by other bacteria and it is natural for bacteria to develop resistance through genetic changes for this reason4. However, our use of antibiotics in modern medicine presents the need to prevent this from happening too often. We are now accustomed to the various campaigns to reduce antibiotic abuse in human healthcare, yet animal agriculture accounted for a third of UK antibiotic use in 201613. Fortunately, many measures are now being taken to reduce the overuse of antibiotics in animals, but while global demand for animal products continues to rise4, the demand for antibiotics will too.

SARS-SoV-2, the viral cause of COVID-19, the zoonotic origin of which is yet to be confirmed. Source: CDC



Domesticated animals now account for 60% of the land vertebrate biomass of the planet, while wild animals only make up 4%14.  
Humans are the other 36%. This loss of bio-diversity is thought to increase the risk of new zoonoses in a few ways, though this concept is not yet fully understood4. One such example is in the spread of zoonotic viruses by mosquitos and ticks – where native vertebrate diversity is high, they feed from a greater variety of hosts, of which only a few are good reservoirs for the virus, leading to fewer infections15.
 
Paradoxically, the Increasing demand for land for resource-intensive livestock is in turn increasing wild animal-human interface, which also increases the risk of zoonoses jumping species to humans4.
Our growing demand for land and resources forces us to further encroach on wild habitats. Cattle in particular require vast amounts of land and crops, which is driving deforestation in places like the Amazon16. While habitats decline, wild animals are forced closer to human and livestock populations. This increases contact between livestock, wild animals, and humans.

Many zoonoses are already found in animal agriculture as foodborne diseases, such as salmonella, listeria and campylobacter.
Animals are a major source of foodborne pathogens, even in plants after contamination with animal waste4. Animal-sourced foods formed 35% of the global burden of foodborne disease in 201017, and 2018-19 saw the largest-ever outbreak of listeriosis after 1000 laboratory-confirmed cases in South Africa and over 200 deaths as a consequence.

The number of outbreaks caused by zoonoses is rising, including relative to outbreaks caused by human-specific pathogens.
The total height of the bars represents the total number of outbreaks of disease; red area show the proportion of outbreaks that were caused by zoonoses as opposed to pathogens limited to humans (blue area). Adapted from Smith et al., 201418 .

So is animal agriculture increasing the risk of disease and pandemics? The UN seems to think so⁴. In their 2020 report, ‘preventing the next pandemic’, increasing human demand for animal protein was listed as the first of 7 drivers of pandemics and as a contributing factor to other drivers listed,  such as unsustainable agricultural intensification and climate change.

It should be noted that in in lesser-economically developed regions with poor food security, animal products serve as an important source of nutrition that goes some way towards maintaining a healthy immune system and thus reducing the burden of disease4. Therefore, the answer is not as simple as everyone simply dropping animal products from the diet right now.

However we are now well aware, diseases do not respect borders and pandemics are worldwide. If we hope to prevent them in future, it will take global change in practices, and when both farming livestock and interacting with wild animals appears to increase the risk of disease, it seems ever-more likely that this will have to involve reducing our consumption of animal products.

References

1. Host range and emerging and reemerging pathogens. Woolhouse, MEJ and Gowtage-Sequeria, S. 2005, Emerging Infectious Diseases, Vol. 11, pp. 1842–1847. Doi: 10.3201/eid1112.050997.
2. Emerging diseases go global. Woolhouse, Mark E. J. 2008, Nature, Vol. 451, pp. 898–899. Doi.org/10.1038/451898a.
3. Risk factors for human disease emergenceTaylor, LH, Latham, SM and Woolhouse, MEJ. 1411, s.l. : 2001, Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 356, pp. 983–989. Doi: 10.1098/ rstb.2001.0888.
4. United Nations Environment Programme and International Livestock Research Institute. Preventing the Next Pandemic: Zoonotic diseases and how to break the chain of transmission. Nairobi, Kenya. : United Nations Environment Programme, 2020. ISBN No: 978-92-807-3792-9.
5. Origins of the 2009 H1N1 influenza pandemic in swine in MexicoMena, Ignacio, et al. 2016, eLife, Vol. 5, p. e16777. Doi: 10.7554/eLife.16777.
6. Food and Agriculture Organization of the United Nations. FAOSTAT: Data. [Online] http://www.fao.org/faostat/en/#data.
7. Department for Environment, Food and Rural Affairs. Code of practice for the welfare of meat chickens and meat breeding chickens. [Online] 2018. https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/694013/meat-chicken-code-march2018.pdf.
8. United States Department of Agriculture. Meat and Poultry Labeling Terms. [Online] 2015. https://www.fsis.usda.gov/wps/portal/fsis/topics/food-safety-education/get-answers/food-safety-fact-sheets/food-labeling/meat-and-poultry-labeling-terms/meat-and-poultry-labeling-terms/!ut/p/a1/jZFRb4IwEMc_DY-lx3AG90ZIFmUTZsxm5WUpehSS0pK2jrhPP9wyExed9p569.
9. Does genetic diversity limit disease spread in natural host populations? King, K. C. and Lively, C. M. 4, 2012, Heredity, Vol. 109, pp. 199–203. Doi: 10.1038/hdy.2012.33.
10. Investigation of risk factors for Salmonella on commercial egg-laying farms in Great Britain, 2004-2005. Snow, L C, et al. 19, 2010, British Veterinary Association, Vol. 166, pp. 579-86. Doi: 10.1136/vr.b4801.
11. The animal-human interface and infectious disease in industrial food animal production: rethinking biosecurity and biocontainmentGraham, J. P., et al. 3, 2008, Public Health Reports, Vol. 123, pp. 282–299. Doi: 10.1177/003335490812300309
12. Antibiotic Abuse in Animal Agriculture: Exacerbating Drug Resistance in Human PathogensGoldman, Emanuel. 1, 2004, Human and Ecological Risk Assessment: An International Journal, Vol. 10, pp. 121-134. Doi: 10.1080/10807030490281016.
13. The Parliamentary Office of Science and Technology. Reducing UK Antibiotic Use in Animals. [Online] 2018. researchbriefings.files.parliament.uk%2Fdocuments%2FPOST-PN-0588%2FPOST-PN-0588.pdf&usg=AOvVaw2I1wEWBrrsqTAVI2.
14. The biomass distribution on EarthBar-On, Yinon M., Phillips, Rob and Milo, Ron. 25, 2018, PNAS, Vol. 115, pp. 6506-6511. Doi: 10.1073/pnas.1711842115.
15. Biodiversity loss and the rise of zoonotic pathogens. Ostfeld, RS. Suppl 1, 2009, Clinical microbiology and infection, Vol. 15, pp. 40-43. Doi: 10.1111/j.1469-0691.2008.02691.x.
16. Persistence of cattle ranching in the Brazilian Amazon: A spatial analysis of the rationale for beef production. Bowman, Maria S., et al. 3, 2012, Land Use Policy, Vol. 29, pp. 558-568. Doi: 10.1016/j.landusepol.2011.09.009.
17. Global disease burden of pathogens in animal source foods, 2010. Li, Min, et al. 6, 2019, Plos One, Vol. 14, p. e0216545. Doi: 10.1371/journal.pone.0216545.
18. Global rise in human infectious disease outbreaks. Smith, Katherine F., et al. 2014, Journal of the Royal Society, Vol. 11, p. 20140950. Doi: 10.1098/rsif.2014.0950.19.

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